Survival skills in Laguna Woods are techniques that a person may use in order to sustain life in any type of natural environment or built environment. These techniques are meant to provide basic necessities for human life which include water, food, and shelter. The skills also support proper knowledge and interactions with animals and plants to promote the sustaining of life over a period of time. Practicing with a survival suit An immersion suit, or survival suit is a special type of waterproof dry suit that protects the wearer from hypothermia from immersion in cold water, after abandoning a sinking or capsized vessel, especially in the open ocean.
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Survival skills are often associated with the need to survive in a disaster situation in Laguna Woods .
 Survival skills are often basic ideas and abilities that ancients invented and used themselves for thousands of years.
 Outdoor activities such as hiking, backpacking, horseback riding, fishing, and hunting all require basic wilderness survival skills, especially in handling emergency situations. Bush-craft and primitive living are most often self-implemented, but require many of the same skills.
If you are planning to go on an outdoor survival trip, be sure you are physically and mentally able and prepared for such a daring and risky adventure.We suggest you take the time to gather some notes and plan your trip way in advance. All though this will be an awesome experience, and a lot of fun, it could be very dangerous and potentially life threatening if not prepared for it. There is a big difference between hiking or camping then going on a real live survival trip. A survival trip means your only taking accentual items to live off of. A survival trip is not for the beginning hiker or camper, but for the experience outdoor enthusiast, an outdoor person that has done a lot of hiking, camping, fishing or hunting in the wilderness, or has had some kind of military experience in the wilderness. One thing for sure, is to never try to do something like this on your own, always have a partner or two to go with you.Depending on what kind of trip your going to take, you need to give it a lot of thought. Do you have all the right outdoor gear that your going to need to survive? Are you going to take a trip for a week, a month or several months? Are you going to the mountains or a desert? Are you taking a trip in the wilderness or just in the back woods?There are many different types or ways of taking a survival trip. Like, you could take a trip threw the swamps of Louisiana, or a wilderness trip threw the hills of Yellowstone Park in Wyoming. No matter where you decide to go, it takes a lot of planning and preparation. By all rights, it would be wise to plan many months ahead.What kind of outdoor gear and how much are you going to take? What route are you going to take? What time of the year do you want to go? Is it going to be extremely cold or unbearably hot? Is it going to be hot in the daytime and cold at night? Are there going to be any rivers to cross or canyons to scale? Are you going to be able to get in touch of the outside world, if there was an emergency? I could go on and on about things that could go wrong, and that's why it takes a lot of planning.If you are an experienced outdoor enthusiast and have quite a bit of knowledge in hiking and camping, but have never been in, or done a real life survival trip, I believe you would like to take your first trip to the Appalachian Trail in the eastern United States.The Appalachian Trail is a marked trail for hikers and campers. It is approximately 2,200 miles long and runs from the state of Georgia all the way to Maine. It is the longest continuous marked trail in the United States. The Appalachians offer some of the most beautiful sites of landscape that America has. There is some pretty big rivers that you are going to have to cross too. These rivers also provide some mighty fine fishing also. Even though it is a marked trail for hikers and campers, it still offers an awesome challenge to under take and would be a great achievement for anyone that has never done a real life survival trip.To just get out and hike this whole trail from south to north or vice verses, would take you about 6 to 7 months if you wanted to do the whole trip at one time. There are plenty of small towns to get to off the trail if you needed to stock up on supplies, but that is just like taking a long hiking trip instead of a real life survival trip.A survival trip consists of getting off the beaten path and actually live off the land, another words, do it the hard way. Yes, this is just like taking a hiking trip, but if you take and live it the hard way and do things that are unnatural like starting your campfire with two sticks or getting your water from little ponds and creeks and having to boil your water to purify it, and eating things like worms or grub worms, eating berries and mushrooms and so forth, then your doing it the hard way. Finding or building a shelter from mother nature instead of pitching a tent is a great experience. Making and setting snares to catch animals like rabbit, squirrel or wild pigs so you can eat is a great experience. Finding certain plants that hold water that you could drink is another good experience.Make sure that when you do plan a trip, study up and get information on the area you will be going in. You need to know what type of edible plants there are. What kind of animals inhabit there? Are there animals of prey, like bear or mountain lion, or even wolves? Are there snakes, and how many different species, and are they venomous or not? What kind of insects or spiders are there, and are they venomous?Doing things like this is all part of survival, and this is a good learning and training experience. You may never know when something bad could happen, so you need to be prepared for the worse. Remember, this is only a practice survival trip and not a real one, but if you don't plan it well, it could go awfully wrong for you and turn in to a real life survival situation.For more information on the Appalachian mountains, look it up on the web or call just about any of the eastern states of commerce for literature and maps.You can find more outdoor survival articles of mine and other well known authors at many other article directories sites. Gather all the information you can get before taking on such a wonderful adventure.
Jump to navigation Jump to search Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse". In oncology, PFS usually refers to situations in which a tumor is present, as demonstrated by laboratory testing, radiologic testing, or clinically. Similarly, "disease-free survival" is when patients have had operations and are left with no detectable disease. Time to progression (TTP) does not count patients who die from other causes but is otherwise a close equivalent to PFS (unless there are a large number of such events). The FDA gives separate definitions and prefers PFS. PFS is widely used in oncology. Since (as already said) it only applies to patients with inoperable disease[dubious – discuss] that are generally treated with drugs (chemotherapy, target therapies, etc.) it will mostly be considered in relation to drug treatment of cancer. A very important aspect is the definition of "progression" since this generally involves imaging techniques (plain radiograms, CT scans, MRI, PET scans, ultrasounds) or other aspects: biochemical progression may be defined on the basis of an increase in a tumor marker (such as CA125 for epithelial ovarian cancer or PSA for prostate cancer). At present any change in the radiological aspect of a lesion is defined according to RECIST criteria. But progression may also be due to the appearance of a new lesion originating from the same tumor or to the appearance of new cancer in the same organ or in a different organ, or due to unequivocal progression in 'non-target' lesions—such as pleural effusions, ascites, leptomeningeal disease etc. Progression-free survival is often used as an alternative to overall survival (OS): this is the most reliable endpoint in clinical studies, but it will only be available after a longer time than PFS. For this reason, especially when new drugs are tested, there is a pressure (that in some cases may be absolutely acceptable while in other cases may hide economical interests) to approve new drugs on the basis of PFS data rather than waiting for OS data. PFS is considered as a "surrogate" of OS: in some cancers the two elements are strictly related, but in others they are not. Several agents that may prolong PFS do not prolong OS. PFS may be considered as an endpoint in itself (the FDA and EMEA consider it such) in situations where overall survival endpoints may be not feasible, and where progression is likely or very likely to be related to symptomatology. Patient understanding of what prolongation of PFS means has not been evaluated robustly. In a time trade off study in renal cancer, physicians rated PFS the most important aspect of treatment, while for patients it fell below fatigue, hand foot syndrome, and other toxicities. <Park et al> There is an element that makes PFS a questionable endpoint: by definition it refers to the date on which progression is detected, and this means that it depends on which date a radiological evaluation (in most cases) is performed. If for any reason a CT scan is postponed by one week (because the machine is out of order, or the patients feels too bad to go to the hospital) PFS is unduly prolonged. On the other hand, PFS becomes more relevant than OS when in a randomized trial patients that progress while on treatment A are allowed to receive treatment B (these patients may "cross" from one arm of the study to the other). If treatment B is really more effective than treatment A it is probable that the OS of patients will be the same even if PFS may be very different. This happened for example in studies comparing tyrosine kinase inhibitors (TKI) to standard chemotherapy in patients with non-small cell lung cancer (NSCLC) harboring a mutation in EGF-receptor. Patients started on TKI had a much longer PFS, but since patients that started on chemotherapy were allowed to receive TKI on progression, OS was similar. The relationship between PFS and OS is altered in any case in which a successive treatment may influence survival. Unfortunately this does not happen very often for second-line treatment of cancer, and even less so for successive treatments. The advantage of measuring PFS over measuring OS is that PFS appears sooner than deaths, allowing faster trials and oncologists feel that PFS can give them a better idea of how the cancer is progressing during the course of treatment. Traditionally, the U.S. Food and Drug Administration has required studies of OS rather than PFS to demonstrate that a drug is effective against cancer, but recently[when?] the FDA. has accepted PFS. The use of PFS for proof of effectiveness and regulatory approval is controversial. It is often used as a clinical endpoint in randomized controlled trials for cancer therapies. It is a metric frequently used by the UK National Institute for Health and Clinical Excellence and the U.S. Food and Drug Administration to evaluate the effectiveness of a cancer treatment. PFS has been postulated to be a better ("more pure") measure of efficacy in second-line clinical trials as it eliminates potential differential bias from prior or subsequent treatments. However, PFS improvements do not always result in corresponding improvements in overall survival, and the control of the disease may come at the biological expense of side effects from the treatment itself. This has been described as an example of the McNamara fallacy.
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